学　术

　　为搭建我校博士后之间的学术交流平台，促进学术水平提升，学校博士后管理办公室组织开展博士后学术沙龙活动。本次沙龙由我校博士后汪子琪、姚文坡和朱彬分享其研究成果，诚挚邀请感兴趣的师生参加。

　　一、时　间：2021年6月18日（周五）14：30

　　二、地　点：清水河校区经管楼宾诺咖啡

　　三、主办单位：电子科技大学博士后管理办公室

　　四、承办单位：生命科学与技术学院  电子科技大学博士后联谊会

　　五、活动安排：

　　报告一：     

　　（1）主题：Light-Sensitive Pathway and Brain Aging

　　（2）主讲人：汪子琪  生命科学与技术学院博士后 

　　（3）交流内容：

　　In this talk, we briefly discuss five parts of light-sensitive pathway and brain aging: (1) Trait- and State- dependence of brain aging; (2) light-sensitivity brain pathway, especially the learning and memory pathway; (3) Altered functional connectivity of light-sensitivity pathway across the lifespan in the normal cognition people; (4) Altered functional connectivity of light-sensitivity pathway across the lifespan in the Alzheimer's disease risk people (subjective cognitive decline, SCD); (5) Exploration on the blue and green light in the Alzheimer's disease risk people.

　　（4）主讲人简介：

　　Ziqi Wang received the Ph.D. degree from the Capital Medical University of Neurology, in 2017 and 2019, respectively. She is the deputy chief physician of neurology. She currently works as a Postdoctoral Fellow in the School of Life Science and Technology of UESTC. Dr. Wang is working in the field of Alzheimer’s disease and aging. Her main research interests include functional magnetic resonance study of the early stage of Alzheimer's disease, sleep, mood, and aging brain.

　　报告二：

　　（1）主题：排列时间不可逆分析的若干问题

　　（2）主讲人：姚文坡  生命科学与技术学院博士后

　　（3）交流内容：

　　时间不可逆是衡量系统非平衡性特征的有效指标，其在非线性特征分析中也发挥了重要作用。然而，由于需要计算对应序列的联合概率差异性，时间不可逆的量化并非易事。排列类型由于和联合概率的计算有密切关系并且包含向量结构化特征，在系统时间不可逆分析中受到广泛的关注。在系统的排列时间不可逆分析中，需要考虑空排列和等值元素的影响，并且注意排列类型和向量空间结构的关系，否则可能带来时间不可逆量化分析的不足甚至概念性的偏差。总之，厘清排列时间不可逆分析中相关问题有助于对系统非平衡特征的理解和量化。

　　（4）主讲人简介：

　　姚文坡，本科毕业于江苏大学，硕士、博士毕业于南京邮电大学，研究方向为信号与信息处理。

　　报告三：

　　（1）主题：Synaptic excitability changes within the hippocampal formation of 3xTg AD mice

　　（2）主讲人：朱彬 　生命科学与技术学院博士后

　　（3）交流内容：

　　Medial temporal lobe contains amygdala, entorhinal cortex and hippocampus within complex connections. The connections from basolateral amygdala nucleus to entorhinal cortex, as well as the entorhinal cortex to dentate gyrus were believed to play an important role in declarative memory. Alzheimer’s disease is the main disease cause dementia. One of the most common symptoms of AD is the deficits in declarative memory. The post mortem studies found that medial temporal lobe is the main region showing the pathological changes. So far, 3 aspects of pathological changes including β-amyloid accumulation, hyperphosphorylated tau protein, as well as neuron loss were found in AD brain. Among those 3 changes, β-amyloid accumulation appeared earliest in the brain and was believed as a trigger of other pathological changes. The toxicity of intracellular β-amyloid in brain and cultured cell was reported. But the relation between functional changes and intracellular β-amyloid accumulation is still unclear.

　　In this project, both in vivo and in vitro electrophysiological technic were involved to find possible functional changes in the connection between BLP to EC, EC to DG in 3 and 6-month old 3xTg-AD mice (with only intracellular β-Amyloid accumulation, absence of extracellular plaques and pTau caused neurofibrillary tangles). In vivo, we stimulate BLA region and recording in EC and DG simultaneously. In vitro, BLA region was stimulated and EC was recorded; then, EC was stimulated and recording electrode was move to DG region.

　　In order to achieve the aim of project, the connectivity of mentioned connection was tested first. The input/output curve has been built by involved a range of single stimulations in different intensities. From the results, the connectivity was found decreasing in both EC and DG regions in only 6-month 3xTg-AD mice comparing with age matched control group in both in vivo and in vitro experiment. The result shows a clear age-strain interaction. Considering about pathological development in the mice model, 6-month-old mice showed more separated and concentrated intracellular β-amyloid accumulation. This result suggests a concentration-dependent manner.

　　Then, we focus on neuronal short-term plasticity by set up a serious of paired-pulse in different intervals. Field potential was recorded. Paired-pulse index has been calculated. Generally, in both 3- and 6-month-old 3xTg-AD mice, the inhibition which were found in control mice were found deficit. Furthermore, the inhibitory effect in control group can be blocked by CGP55845, a GABAb receptor antagonist while the drug has no effects in 3xTg-AD group. It suggests that GABAb receptor mediated inhibition may blocked in 3xTg-AD mice.

　　（4）主讲人简介：

　　Bin Zhu, received his Ph.D in University of Manchester in 2019. Now, Bin Zhu working in UESTC as postdoc in School of Bio-science and technology. The main research interests are: Cognitive neuroscience, neuron degeneration desease.

　　　　　　　　　　　　　　　　　电子科技大学博士后管理办公室

　　　　　　　　　　　　　　　　　　　　2021年6月16日